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The AIDS world is reeling. Doctors, researchers and activists were aboard Malaysian Airlines flight MH17, which was shot out of the sky on Thursday; they were headed to the International AIDS Conference in Melbourne.

The nearly 300 passengers on the plan were all killed. Twitter users were among the first to report the loss of leading figures in the fight against AIDS, including Dutch researcher Joep Lange, former president of the International AIDS Society.

What a HUGE loss to the world. Just learned that dear friend, amazing father to 5 girls and veteran AIDS researcher Joep Lange was on #MH17

— Dr. Seema Yasmin (@DoctorYasmin) July 17, 2014